peripheralbloodsmear

Disease Overview

CLL (Chronic Lymphocytic Leukemia) Complete Guide: PBS Findings, Clinical Features, Diagnosis, and Prognosis
ByCDL.MD.phD. 2026-02-042026-02-13

CLL (Chronic Lymphocytic Leukemia) Complete Guide: PBS Findings, Clinical Features, Diagnosis, and Prognosis Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults and is characterized by the abnormal proliferation of mature B lymphocytes. These cells gradually accumulate in the bone marrow, peripheral blood, and lymphoid tissues, leading to progressive immune dysfunction. 1️⃣ Key…

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Disease Overview

CML (Chronic Myeloid Leukemia) Explained: Stages, PBS Findings, Symptoms, and Prognosis
ByCDL.MD.phD. 2026-02-042026-02-13

CML (Chronic Myeloid Leukemia) Explained: Stages, PBS Findings, Symptoms, and Prognosis Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm in which immature myeloid cells proliferate abnormally in the bone marrow.One of its most defining features is the Philadelphia chromosome (t(9;22)(q34;q11)), found in the majority of patients. This genetic abnormality plays a pivotal role in diagnosis,…

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Hematology

🔬 What Does “Left Shift” Mean in a CBC Report?
ByCDL.MD.phD. 2026-02-032026-02-13

🔬 What Does “Left Shift” Mean in a CBC Report? You may occasionally notice the term “left shift” on a complete blood count (CBC) report. This phrase refers to an increase in immature granulocytes—cells that should normally remain inside the bone marrow until fully matured. In other words, under normal physiology, granulocytes follow the sequence:Bone…

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Hematology

WBC Differential Count test
ByCDL.MD.phD. 2026-02-032026-02-13

WBC Differential Count — A Key Hematology Test for Identifying Infection, Inflammation, and Hematologic Disorders The WBC Differential Count is an essential component of the Complete Blood Count (CBC), providing both the relative proportion and absolute number of each white blood cell type.This test plays a crucial role in evaluating infections, inflammatory conditions, allergic diseases,…

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Case Discussions

EDTA-Dependent Pseudothrombocytopenia
ByCDL.MD.phD. 2026-02-022026-03-25

EDTA-Dependent Pseudothrombocytopenia: What It Is and Why It Matters Key Takeaway: EDTA-dependent pseudothrombocytopenia (PTCP) is a laboratory artifact — not a true platelet disorder — caused by platelet clumping in EDTA-anticoagulated blood tubes, leading to falsely low platelet counts that can be misinterpreted as clinically significant thrombocytopenia. What Is Pseudothrombocytopenia? When a routine complete blood…

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